Cell division resets polarity and motility for the bacterium Myxococcus xanthus.
نویسندگان
چکیده
Links between cell division and other cellular processes are poorly understood. It is difficult to simultaneously examine division and function in most cell types. Most of the research probing aspects of cell division has experimented with stationary or immobilized cells or distinctly asymmetrical cells. Here we took an alternative approach by examining cell division events within motile groups of cells growing on solid medium by time-lapse microscopy. A total of 558 cell divisions were identified among approximately 12,000 cells. We found an interconnection of division, motility, and polarity in the bacterium Myxococcus xanthus. For every division event, motile cells stop moving to divide. Progeny cells of binary fission subsequently move in opposing directions. This behavior involves M. xanthus Frz proteins that regulate M. xanthus motility reversals but is independent of type IV pilus "S motility." The inheritance of opposing polarity is correlated with the distribution of the G protein RomR within these dividing cells. The constriction at the point of division limits the intracellular distribution of RomR. Thus, the asymmetric distribution of RomR at the parent cell poles becomes mirrored at new poles initiated at the site of division.
منابع مشابه
Cell division resets polarity and motility for the bacterium Myxococcus 1 xanthus
3 Running title: Myxococcus xanthus cell division resets polarity 4 5 Cameron W. Harvey, Chinedu S. Madukoma, Shant Mahserejian, Mark S. Alber, 6 Joshua D. Shrout 7 Department of Applied and Computational Mathematics and Statistics, University of Notre 8 Dame, Notre Dame, IN, 46556; USA 9 Department of Physics, University of Notre Dame, Notre Dame, IN, 46556; USA 10 Department of Civil and Envi...
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عنوان ژورنال:
- Journal of bacteriology
دوره 196 22 شماره
صفحات -
تاریخ انتشار 2014